Din presa - despre infertilitate si/sau reproducere asistata

Informatii si discutii despre proceduri de fertilizare in vitro si inseminare artificiala, despre medici si tratamente, in Romania & abroad.
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Re: Din presa - despre infertilitate si/sau reproducere asis

Mesajde SOS Infertilitatea » Lun Iun 03, 2013 3:26 pm

Breaking News – New stimulation protocol for Poor Responders

Double stimulation and egg collection, the best protocol for poor responders, reported by Prof. Yanping Kuang and his team from the IVF Unit in Shanghai.

A unique stimulation protocol was developed by the team of Prof. Kuang at the Shanghai Ninth People’s Hospital affiliated to Shanghai Jiao Tong University School of Medicine, China.

This protocol is based on double stimulation during the same cycle, using letrozole, clomid, hMG and GnRH-agonist. The unique of this protocol is that it ignores the luteal phase, and the second stimulation during the luteal phase allows retrieving more oocyte (which suits the poor responder group) with the eradication of OHSS. More details on the protocol along with comments from Key opinion leaders can be found on IVF-Worldwide.com "Blog" section at the following link . http://www.ivf-worldwide.com/ivf-worldwide-blog.html
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Re: Din presa - despre infertilitate si/sau reproducere asis

Mesajde SOS Infertilitatea » Mar Iun 18, 2013 6:11 am

Amandine, primul bebeFIV din Franta si al patrulea din lume, a devenit mama unei fetite, concepute natural.Amandine a facut publica nasterea fiicei sale pentru a arata ca femeile concepute prin FIV nu au mai multe probleme de fertilitate decat populatia generala.

http://www.allodocteurs.fr/actualite-sa ... 53.asp?1=1
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Re: Din presa - despre infertilitate si/sau reproducere asis

Mesajde SOS Infertilitatea » Mie Iul 10, 2013 10:17 am

In aceste zile ale Congresului ESHRE apar stiri despre noutati in domeniul reproducerii asistate / FIV. Va prezentam trei dintre acestea:

Tehnica ieftina de fertilizare in vitro, pusa la punct de medicii din Belgia

Medicii specialisti in fertilitate din Belgia au dezvoltat o metoda simplificata de fecundare in vitro (IVF), la care ar putea avea acces toate cuplurile din lume care nu au copii si isi doresc unul. Cercetatorii din orasul belgian Genk au declarat ca sunt deja inregistrati 12 copii nascuti in urma aplicarii noii tehnici, care costa mai putin de 300 de dolari.
Una din piedicile in calea clasicei tehnici IVF este pretul, care se poate ridica pana la 5.000 de lire sterline, de exemplu, in Marea Britanie. Institutul pentru fertilitate din Genk a incercat sa simplifice, insa, aceasta metoda, pentru a o face accesibila tuturor cuplurilor doritoare, mai ales a celor din tarile in curs de dezvoltare.
In tehnica IVF obisnuita, trebuie mentinut un nivel ridicat de dioxid carbon in jurul embrionului, pentru a tine sub control nivelul de aciditate. Acest lucru se realiza pana acum cu ajutorul unor incubatoare cu dioxid de carbon, dozatoare de gaz si purificatoare de aer. Cercetatorii belgieni au descoperit o metoda mult mai simpla de a produce dioxid de carbon, aceea de a amesteca acid citric si bicarbonat de sodiu, substante extrem de ieftine. Noua tehnica trebuie testata in continuare, dar implicatiile si rezultatele ar putea fi extrem de importante, au subliniat medicii belgieni.

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Re: Din presa - despre infertilitate si/sau reproducere asis

Mesajde SOS Infertilitatea » Mie Iul 10, 2013 10:18 am

Fumezi in timpul sarcinii si vei avea un baietel? Iata ce se poate intampla!

Gravidele care nu tin cont de avertismentele asupra sanatatii ale fumatului risca sa dea nastere unui copil care va avea mari probleme de fertilitate, in special daca discutam de un copil de sex masculin.

Studii realizate in ultimii 20 de ani arata in mod evident o scadere a calitatii spermei, deci si o reducere a natalitatii si o crestere semnificativa a cuplurilor care se confrunta cu infertilitatea.

Cauzele acestor probleme sunt diverse si includ factorii de mediu, cum este expunerea la toxinele din fumul de tigara, stilul de viata reprezentat de regimul alimentar dezordonat, lipsa de miscare si somnul insuficient, potrivit csid.ro.

Studiul a avut in vedere un esantion de 2,900 de femei insarcinate si tinerea sub observatie a copiilor acestora pana la varsta de 20-22 de ani, cand le-au fost prelevate mostre de sperma si le-au fost masurate nivelurile hormonale. Rezultatele nu sunt deloc imbucuratoare: unul din 6 barbati ale caror mame au fumat in timpul sarcinii aveau probleme cu calitatea spermei si, deci, un risc crescut de infertilitate.

Cercetarea a fost publicata pe larg in cadrul intrunirii anuale a Societatii Europene de Reproducere Umana si Embriologie din Londra.

Sursa.
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Re: Din presa - despre infertilitate si/sau reproducere asis

Mesajde SOS Infertilitatea » Mie Iul 10, 2013 10:18 am

IVF baby born using revolutionary genetic-screening process

Next-generation sequencing could enable IVF clinics to determine the chances of children developing diseases

The first IVF baby to be screened using a procedure that can read every letter of the human genome has been born in the US.

Connor Levy was born on 18 May after a Philadelphia couple had cells from their IVF embryos sent to specialists in Oxford, who checked them for genetic abnormalities. The process helped doctors at the couple's fertility clinic in the US select embryos with the right number of chromosomes. These have a much higher chance of leading to a healthy baby.

The birth demonstrates how next-generation sequencing (NGS), which was developed to read whole genomes quickly and cheaply, is poised to transform the selection of embryos in IVF clinics. Though scientists only looked at chromosomes – the structures that hold genes – on this occasion, the falling cost of whole genome sequencing means doctors could soon read all the DNA of IVF embryos before choosing which to implant in the mother.

If doctors had a readout of an embryo's whole genome, they could judge the chances of the child developing certain diseases, such as cancer, heart disease or Alzheimer's.

Marybeth Scheidts, 36, and David Levy, 41, had tried another fertility treatment, called intrauterine insemination (IUI), three times without success before they signed up for IVF at Main Line Fertility clinic in Pennsylvania.

As part of an international study with Dagan Wells, a fertility specialist at Oxford University, the couple were offered NGS to check their IVF embryos for abnormal chromosomes. Abnormal chromosomes account for half of all miscarriages.

The chances of an embryo having the wrong number of chromosomes rises with the mother's age, and potentially with the father's. For women in their 20s, one in 10 embryos may have the wrong number of chromosomes, but for women in their 40s, more than 75% can be faulty.

Most of the time, embryos with abnormal chromosomes fail to implant in the womb. Those that do are usually miscarried. The portion that survive to full term are born with genetic disorders, such as Down's syndrome and Turner syndrome.

After standard treatment at the US clinic, the couple had 13 IVF embryos to choose from. The doctors cultured the embryos for five days, took a few cells from each and sent them to Wells in Oxford for genetic screening. Tests showed that while most of the embryos looked healthy, only three had the right number of chromosomes.

"It can't make embryos better than they were in the beginning, but it can guide us to the best ones," said Wells.

Based on the screening results, the US doctors transferred one of the healthy embryos into Scheidts and left the rest in cold storage. The single embryo implanted, and nine months later Connor was born. Details of the study will be given at the European Society of Human Reproduction and Embryology (Eshre) meeting in London on Monday.

"I think it saved us a lot of heartache," Scheidts told the Guardian. "My insurance covered me for three cycles of IVF. We might have gone through all three without the doctors picking the right embryos. I would not have a baby now."

A second baby who had the same genetic screening is due to be born next month, after a US couple had IVF at New York University fertility centre.

Doctors can already screen embryos for abnormal chromosomes using a technique called Array CGH, but the procedure adds more than £2,000 to the cost of IVF. Wells said NGS could bring the cost down by a third. To check the number of chromosomes is much simpler than reading all of the DNA accurately.

"It is hard to overstate how revolutionary this is," said Michael Glassner, who treated the couple at the Main Line Fertility clinic. "This increases pregnancy rates by 50% across the board and reduces miscarriages by a similar margin. It will be much less expensive. In five years, this will be state of the art and everyone who comes for IVF will have it."

In Britain, doctors are banned from selecting embryos for anything other than the most serious medical reasons. But as scientists learn more about genetic causes of disease, the urge to choose embryos to avoid cancer and other diseases later in life will intensify.

"You can start to have a very scary picture painted if you talk about height and hair colour and so on," said Glassner. "We have to make sure this is used judiciously."

The prospect of "designer babies" is remote for now, even if it were made legal. IVF produces only a dozen or so embryos at best, so the odds that one has all the traits a couple desires are very low. "IVF is still expensive and uncomfortable with no guarantee of a baby at the end. I can't imagine many people wanting to go through the strains of IVF for something trivial," said Wells.

The Oxford team now plans a large trial of the screening procedure to assess how much it boosts pregnancy rates, and which age groups it benefits the most.

Scheidts still has two screened embryos in cold storage, but has not yet decided whether to use them. "We haven't even thought about that. We'll see how the first year goes."

Sursa.
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Re: Din presa - despre infertilitate si/sau reproducere asis

Mesajde SOS Infertilitatea » Dum Iul 14, 2013 10:26 am

Cum contribuie Nirvana şi Metallica la fertilizarea in vitro

Cântecele unor artişti precum Madonna, Nirvana şi Metallica, cresc şansele de fertilizare in vitro a ovulelor umane, afirmă autorii unui studiu recent.


Cercetătorii spanioli au descoperit în cadrul unui studiu recent faptul că piesele lansate de Madonna, Nirvana şi Metallica, „cântate" unor ovule, pe iPod, cresc şansele lor de fertilizare in vitro cu peste cinci procente, informează site-ul revistei New Musical Express. Savanţii spanioli au folosit în acelaşi studiu piese lansate şi de alţi muzicieni de marcă, precum Michael Jackson şi compozitorii Antonio Vivaldi, Wolfgang Amadeus Mozart şi Johann Sebastian Bach. Cercetătorii de la Institutul Marques din Barcelona, o clinică specializată în fertilizarea in vitro, au dezvăluit rezultatele studiului lor la conferinţa anuală organizată de European Society of Human Reproduction and Embriology, la începutul acestei luni, la Londra. După ce au injectat cu spermă peste 1.000 de ovule, acestea au fost plasate în incubatoare. În jumătate dintre ele, mai multe iPod-uri difuzau cântecele unor cunoscuţi intepreţi pop şi operele clasice ale unor compozitori celebri. Ovulele plasate în incubatoarele în care se aflau iPod-urile au prezentat o rată de fertilizare mai mare cu cinci procente. Oamenii de ştiinţă sunt de părere că vibraţiile create de muzică ajută trecerea nutrimentelor în structura ovulelor şi stimulează eliminarea reziduurilor celulare. Medicul Dagan Wells de la Universitatea Oxford, care nu a luat parte la acest studiu, consideră că şi muzica techno ar putea avea un efect benefic asupra fertilizării in vitro, datorită sunetelor sale joase şi ritmate.

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Re: Din presa - despre infertilitate si/sau reproducere asis

Mesajde SOS Infertilitatea » Lun Iul 15, 2013 1:15 pm

Grupa de sange influenteaza fertilitatea

Grupa de sange influenteaza fertilitatea femeilor prin modularea rezervei ovariene. Nu e vorba de factorul Rh, pozitiv sau negativ, ci de sistemul AB0 cu grupele 0 I, A II, B III sau AB IV.

Informatia a fost prezentata la intalnirea anuala a American Society for Reproductive Medicine (ASRM) din Denver.

Studiile au avut la baza un lot de 560 de femei care au apelat la fertilizare in vitro. Parametrul urmarit a fost nivelul hormonului foliculostimulant (FSH), acesta oferind o imagine asupra rezervei functionale ovariene. Cu cat nivelul FSH este mai mare, cu atat rezerva ovariana este mai mica, avand ca semnificatie clinica un numar redus de ovule disponibile.

FSH se dozeaza in ziua 3 a ciclului menstrual si are valori normale intre 3 – 20 mIU/ml, dar acest interval se imparte in alte 3 in functie de rezerva ovariana astfel:
- 3 – 10 rezerva ovariana buna
- 10 – 13 rezerva ovariana diminuata
- 13+ ovare greu de stimulat.

Rezerva ovariana scade drastic la sfarsitul anilor 30, inceputul anilor 40 pentru a deveni nula la menopauza.

Dupa ce s-au facut corelatiile cu varsta, s-a observat ca in cazul femeilor cu grupa O I, sansa de a avea valoarea FSH peste 10 mIU/mL este de 2 ori mai mare decat in cazul oricarei alte grupe. Grupele cu antigenul A (A II si AB IV) par sa fie protejate de aceasta diminuare a rezervei ovariene.

FSH este doar unul dintre markerii fertilitatii, deci nu se poate spune clar deocamdata ca femeile cu grupa O I au fertilitatea (in ansamblu) diminuata comparat cu celelalte grupe de sange.

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Re: Din presa - despre infertilitate si/sau reproducere asis

Mesajde SOS Infertilitatea » Mie Aug 14, 2013 5:55 am

A propos de lupta celebritatilor cu infertilitatea, un articol interesant in TIME.


Coming Out of the Fertility Closet


In fact, infertility is one of the last great cultural taboos. One survey of infertile couples found that 61% hid their infertility from family and friends, and half didn’t share it with their mothers.


When actresses Sarah Jessica Parker and Nicole Kidman revealed they had used surrogates, they were accused of hiring these other women in order to spare their own bodies from the ravages of pregnancy — as if these women chose this route for cosmetic reasons, when both had publicly shared their battles with infertility.


While celebrities take a lot of flak for exposing their private lives, these are important gestures of support to all the families who are suffering in silence. Such honesty is also welcomed by fertility doctors who struggle to educate patients about the challenges of getting pregnant in your 40s, when popular culture makes it look so easy. Many Hollywood actresses, they explain, became pregnant using donor eggs. Hopefully, one day, the stars will feel comfortable telling us that fact themselves.


“In Hollywood, you can talk about your drug addiction or divorce, but not infertility.” Perhaps that’s starting to change.
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Re: Din presa - despre infertilitate si/sau reproducere asis

Mesajde SOS Infertilitatea » Joi Aug 15, 2013 8:35 pm

Boala celiacă la adulţi manifestată ca infertilitate

Jurnalul Medical Ulster, Volumul 57, No. 1, pp. 88 – 89, April 1988. J P McCann, D P Nicholls, J A Verzin, Acceptat 26 Ianuarie 1988.

PREZENTARE DE CAZ Boala celiacă la adulţi se manifestă de obicei cu simptome gastrointestinale, însă rareori a fost recunoscută drept o cauză a infertilităţii.

Prezentăm un caz în care instituirea unei diete făra gluten, a fost urmată de concepţia încununată de succes.

ISTORICUL CAZULUI O femeie cu vârsta de 21 ani, s-a prezentat la Mater Infirmorum Hospital în 1983. Fusese căsătorită de doi ani şi a încercat să rămână însărcinată timp de 1 an. Anterior a administrat un contraceptiv oral combinat, pentru o perioadă de nouă luni. Nu a fost obţinut un istoric clinic necorespunzător, şi în special nu exista un istoric al menstruaţiilor neregulate. La examinare, prezenta dezvoltare sexuală secundară normală şi nu existau semne fizice pentru boli sistemice.




Articolul integral.
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Re: Din presa - despre infertilitate si/sau reproducere asis

Mesajde SOS Infertilitatea » Joi Aug 29, 2013 9:56 am

STUDIU: Alimentaţia sănătoasă creşte şansele bărbaţilor de a fi fertili

Bărbaţii ar putea să îşi protejeze fertilitatea de efectele negative ale procesului de îmbătrânire dacă adoptă câteva modificări simple în dietele lor zilnice, optând pentru o alimentaţie sănătoasă.

Bărbaţii care adoptă diete bogate în fructe, legume, carne de peşte şi nuci prezintă mai puţine simptome de deteriorare a ADN-ului din sperma lor. Secretul ar putea consta tocmai în nutrimentele conţinute de aceste alimente, afirmă oamenii de ştiinţă din California.

Potrivit unor studii anterioare, cu cât un bărbat este mai în vârstă cu atât el prezintă un risc mai mare ca ADN-ul lui să fie fragmentat, iar rearanjarea cromozomială din spermă să fie mai pronunţată.

Aceste procese determină un risc mai mare de infertilitate sau de a avea copii cu diverse handicapuri.

Însă o dietă bogată în vitamina C, vitamina E şi în acid folic poate să protejeze structura ADN-ului, în special pentru bărbaţii trecuţi de vârsta de 40 de ani.

Profesorul Simon Fishel, directorul CARE Fertility Group, unul dintre cei mai apreciaţi specialişti din lume în domeniul fertilităţii, consideră că bărbaţii care întâmpină probleme în eforturile lor de a procrea nu ar trebui să subestimeze impactul pe care ar putea să îl aibă alimentaţia.

"Alimentaţia poate avea efecte benefice şi efecte negative. Compuşii denumiţi radicali liberi pot avea un efect vătămător asupra celulelor şi ei se pot concentra în testicule", a spus cercetătorul american.

Unele dintre nutrimentele menţionate, precum vitamina C, indiferent dacă provine din fructe şi legume sau din suplimente, poate să elimine acei radicali liberi şi să împiedice astfel distrugerile la nivelul ADN-ului spermei. Altele, precum zincul, joacă un rol important în menţinerea integrităţii structurale a spermei.

"Însă ceea ce mâncăm poate fi şi dăunător. Compuşii asemănători estrogenului care se strecoară uneori în lanţul alimentar, prin intermediul cărnii de exemplu, pot avea un efect dăunător asupra dezvoltării spermatozoizilor", mai spune acesta.

Aproximativ 3,5 milioane de cupluri din Marea Britanie întâmpină dificultăţi în tentativele lor de a procrea, potrivit sistemului naţional de sănătate din această ţară. Aproximativ 25% din totalul cuplurilor sunt infertile din cauza calităţii slabe a spermei. Calitatea spermei bărbatului poate de asemenea să scadă odată cu înaintarea în vârstă.

Deşi tratamentele de fertilitate pot avea o rată mare de succes, ele sunt scumpe şi necesită timp, iar oamenii de ştiinţă au făcut în ultimii ani tot mai multe studii încercând să afle dacă nu cumva compuşii din alimentaţia zilnică ar putea fi de ajutor.

Cel mai recent studiu realizat în domeniu a arătat faptul că bărbaţii în vârstă de peste 44 de ani care prezentau în organismele lor cele mai ridicate concentraţii de vitamina C, existentă în portocale, ardei, căpşuni, broccoli şi cartofi, prezentau un risc cu 20% mai mic de a suferi deteriorări ale ADN-ului spermei, în comparaţie cu bărbaţii din aceeaşi grupă de vârstă care nu includ aceste alimente în dietele lor.

Rezultate similare s-au înregistrat şi pentru bărbaţii care prezentau în organism concentraţii ridicate de zinc - element chimic prezent în carnea de peşte şi în crustacee -, de vitamina E - prezentă în nuci şi seminţe - şi de acid folic - prezent în frunzele de legume.

Sursa.
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Re: Din presa - despre infertilitate si/sau reproducere asis

Mesajde SOS Infertilitatea » Joi Sep 05, 2013 6:49 am

Femeie căreia i-au fost EXTIRPATE ovarele acum 7 ani, ÎNSĂRCINATĂ cu GEMENI. De ce face istorie

O femeie care a crezut că nu va putea avea niciodată copii este însărcinată cu gemeni şi se pregăteşte să devină mamă pentru prima oară.

Femeia din Brisbane, Australia, a suferit de cancer şi, acum 7 ani, ambele ovare i-au fost extirpate. Înainte de operaţie, ea şi-a rugat doctorii să îi păstreze puţin ţesut ovarian, iar aceştia i-au ascultat rugămintea.

În 2010, Vali, tânăra femeie, a primit o grefă de ţesut, medicii grefând ţesutul ovarian pe peretele său abdominal. În 2012 a mai existat o intervenţie chirugicală iar puţin mai târziu femeia a putut produce două ovule, care au fost fertilizate şi apoi plasate în uterul său, scrie The Telegraph

Ea şi partenerul său de viaţă se pregătesc să devină părinţi. Medicii susţin că e o reuşită extrem de importantă, care le poate oferi o speranţă tuturor celor care şi-au pierdut ovarele în urma unei boli şi au crezut că nu vor putea deveni mame niciodată.

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Re: Din presa - despre infertilitate si/sau reproducere asis

Mesajde SOS Infertilitatea » Joi Sep 26, 2013 5:26 am

De ce nu mai reuşesc femeile să rămână însărcinate? Mii de specialişti lansează un semnal de alarmă

Multe femei din zilele noastre se întreabă „de ce nu reuşesc să rămân însărcinată?”. Acum, două organizaţii importante ce reunesc mii de doctori şi de cercetători lansează un semnal de alarmă, anunţând că abilitatea femeilor de a face copii este afectată de toxinele din mediu.

Două organizaţii importante, The American College of Obstetricians and Gynecologists şi The American Society for Reproductive Medicine, au publicat o opinie comună în care solicită guvernului american să schimbe politicile de mediu şi în care pledează pentru mai multe măsuri din partea doctorilor pentru a preveni expunerea la chimicale în timpul sarcinii.

„În ultimii 5-7 ani s-au adunat foarte multe dovezi care atestă că aceşti contaminanţi de mediu pot afecta în mod negativ sănătatea reproductivă”, afirmă dr. Linda Giudice, preşedintele American Society for Reproductive Medicine, o organizaţie ce reuneşte peste 7.000 de doctori şi cercetători.

Giudice afirmă că în cazul care pacienţii şi cadrele medicale devin mai conştiente de faptul că expunerea la aceste substanţe au un efect nociv, de durată, speranţa este că acestea vor putea fi evitate sau că expunerea poate fi minimizată.

„Prevenirea este un aspect important al sănătăţii reproductive de mediu”, spune Giudice, pentru că agenţii toxici pot fi transmişi mai departe generaţiilor viitoare.

Comitetul a analizat dovezile ştiinţifice pe tema toxinelor preţ de doi ani înainte de a elabora această opinie comună în care subliniază îngrijorările specialiştilor şi în care sugerează diferite acţiuni ce pot fi luate la nivel individual, de către medici şi de către guvern. Opinia comună va fi publicată în ediţia din octombrie a jurnalelor Fertility and Sterility şi Obstetrics and Gynecology.

„Ştim că sarcina este un moment de o vulnerabilitate deosebită, în care femeile trebuie să fie grijulii în ceea ce priveşte expunerea la factorii de mediu”, afirmă dr. Jeanne Conry, preşedintele The American College of Obstetricians and Gynecologists, un grup ce reprezintă aproximativ 57.000 de doctori.

Peste 84.000 de substanţe chimice sunt folosite acum în producere şi procesare, iar 700 de substanţe chimice noi sunt introduse în SUA în fiecare an, spune Conry. Acest lucru se întâmplă pe un fundal în care numărul afecţiunilor precum defectele la naştere, autismul şi cancerul de sân este în creştere.

„Nu putem spune că genele s-au schimbat în ultimii 30-40 de ani, deci e foarte probabil ca mediul să fie de vină”, afirmă Conry. Multe substanţe chimice sunt introduse în mediu fără să fie efectuate cercetări adecvate asupra efectelor lor asupra sănătăţii, spune Conry.

Pentru că aceste chimicale sunt în aer, apă, sol, alimente şi în produsele destinate publicului larg, este greu ca oamenii să-şi limiteze expunerea. Unele grupuri de persoane sunt mai vulnerabile la aceste riscuri toxice decât altele, cum ar fi oamenii cu slujbe care implică o expunere la pesticide şi la substanţe chimice industriale sau oamenii care trăiesc în zone cu un nivel mare al poluării aerului sau cu plumb în clădiri.

De asemenea, alte substanţe, precum mercurul din peşte, poate trece de placentă şi poate ajunge să se acumuleze în făt. Cercetătorii ştiu de mulţi ani că mercurul poate afecta comportamentul copiilor, spune Conry.

De aceea, femeile care iau în plan să devină mame şi cele ce sunt însărcinate sau care alăptează ar trebui să evite să consume peşte bogat în mercur, cum ar fi rechin, peşte-spadă sau macrou şi să aleagă peşti cu un conţinut mai mic de mercur.

De asemenea, femeile ar trebui să spele fructele şi legumele pentru a reduce expunerea la pesticide, ce au fost asociate unui risc sporit de cancer în copilăria noului născut.

Specialiştii recomandă totodată ca femeile să evite produsele cu Bisfenol A, o substanţă aflată în marginile de plastic ale unor alimente şi băuturi vândute la conservă şi care provoacă dereglări hormonale.

„Vrem să contribuim la cunoaşterea oamenilor fără a provoca panică”, afirmă Conry.

„Dacă vom reuşi să creştem nivelul de conştientizare pentru a minimiza expunerea la aceşti factori de mediu, îmbunătăţind astfel sănătatea reproductivă, cred că vom reuşi să îndeplinim un obiectiv major”, concluzionează Giudice.

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Re: Din presa - despre infertilitate si/sau reproducere asis

Mesajde SOS Infertilitatea » Lun Sep 30, 2013 2:31 pm

Research gives hope to IVF couples

SOUTHAMPTON fertility experts have offered hope to childless couples after groundbreaking research revealed that a “choosy uterus” can prevent pregnancy.

The discovery by the University of Southampton shows that the uterus can detect a poor quality embryo and will take action to ensure that it does not embed in the lining.

It is hoped the breakthrough in understanding how the uterus works will open new avenues to develop new treatments to improve the success rate of IVF for couples desperate to start a family.

Getting embryos to implant is still one of the biggest problems in IVF so this research is a huge boost to experts trying to help couples get pregnant.

Professor Nick Macklon, professor of gynecology and obstetrics at the university, who co-led the research, said: “One in six couples will experience some sort of infertility, which can be both frustrating and daunting, and many will turn to IVF.

“But the big problem in IVF is still the low chance of getting embryos to implant. These new insights into how an endometrium chooses an embryo may open new avenues to develop new treatments for this.”

The research revealed that if the embryo quality is poor, the endometrium will subdue a large number of the genes that are involved in determining whether the embryo is accepted.

This results in the embryo being left to disintegrate and the cycle starts again.

Professor Macklon, who is also director of the Complete Fertility Centre, based at the Princess Anne Hospital, said: “Our research has shown that one of the signals which the uterus picks up on in determining the quality of the embryo is the level of trypsin it gives off.

“The lack of trypsin signals appear to indicate to the endometrium that the embryo’s quality is not very high and initiates a reduction in receptivity to implantation.”

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Re: Din presa - despre infertilitate si/sau reproducere asis

Mesajde SOS Infertilitatea » Mie Oct 02, 2013 7:21 am


Baby Breakthrough: Infertile Woman Gives Birth


Surgeons removed the woman's ovaries and coaxed them into producing eggs again, then re-implanted them.

A 30-year-old infertile woman has given birth to a baby in Japan after doctors used a new technique to "reawaken" her ovaries into producing eggs again.

The experimental technique, developed by researchers at Stanford University School of Medicine in California, is in its early stage and was only tried on a small group of Japanese women with a specific kind of infertility problem.

The condition, known as primary ovarian insufficiency, affects about 1% of women and causes the ovaries to stop working before the age of 40.

Egg donation is the only option for women who enter menopause at a young age if they want to attempt to carry a pregnancy.

However, scientists now hope the breakthrough can also help women in their early 40s who have trouble becoming pregnant because of their age.

Medics at the St Marianna University School of Medicine in Kawasaki, Japan, used the technique in an experiment on 27 women who had an average age of 37.

The women stopped menstruating nearly seven years earlier on average and agreed to have both ovaries removed, according to a report published online by the Proceedings of the National Academy of Sciences.

Of this group, 13 women were found to still have residual follicles, which typically contain one immature egg.

Human females are born with about 800,000 of these follicles. Most will remain dormant, but normally one follicle develops to maturity each month and releases an egg.

"Our treatment was able to awaken some of the remaining primordial follicles and cause them to release eggs," said Aaron Hsueh, senior author of the report and professor of obstetrics and gynecology at Stanford University.

The ovaries were dissected and treated with stimulant drugs to block a certain growth pathway that causes the follicles to stay dormant.

Small pieces of the ovaries were then transplanted back into the women, near their fallopian tubes.

Eight of the 13 women showed signs of follicle growth, and were treated with hormones to stimulate ovulation.

From that group, five developed mature eggs, which the researchers harvested for in vitro fertilisation using the sperm of the women's partners.

One woman received two embryos and carried a single pregnancy to term and gave birth to a son in Tokyo last December.

The child was delivered by C-section - because the foetus was in a breech position at 37 weeks - by the report's lead author Kazuhiro Kawamura, associate professor of obstetrics and gynaecology at the St Marianna University.

"Although I believed, based on our previous research, that this in vitro activation (IVA) approach would work, I monitored the pregnancy closely and, when the baby was in a breech presentation, I performed the Caesarean section myself," said Mr Kawamura.

"I could not sleep the night before the operation, but when I saw the healthy baby, my anxiety turned to delight.

"The couple and I hugged each other in tears. I hope that IVA will be able to help patients with primary ovarian insufficiency throughout the world."

He said the mother hoped to have another child with one of the frozen embryos in storage from her treatment.

Of the other four women who also developed mature eggs, one is pregnant, two are preparing for embryo transfer or are undergoing additional egg collection and one woman was implanted with an embryo, but failed to become pregnant.

The researchers are now planning to investigate whether the technique could help counteract other causes of infertility, such as cancer treatment.

Alan Copperman, director of the division of reproductive endocrinology at Mt Sinai Medical Center in New York, said he applauded the US-Japanese team's "novel approach to an age-old problem", but added that it was "extremely premature to comment on the widespread potential for this procedure to help women with ovarian failure to achieve reproductive success".

Other experts expressed caution at the results.

"It shows a lot of promise (but) I don't think it's even close to being ready (for routine use)," said Dr Mark Sauer, of the Columbia University Medical Center in New York.

Dr Amber Cooper, of Washington University, St Louis, said the technique was "very much an experimental method".

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Re: Din presa - despre infertilitate si/sau reproducere asis

Mesajde SOS Infertilitatea » Mie Oct 02, 2013 7:25 am

Male Infertility ‘as important as global warming’

Leading Irish fertility clinic, ReproMed warns that male infertility continues to be a growing problem.

A study from the European Science Foundation (ESF) has revealed a rapid increase in male infertility over the past few decades.

Whilst 1 in 6 people in Ireland are affected by infertility, and traditionally it was believed that 90% of infertility issues lay with women, contemporary statistics reveal that in fact, 40% of infertility issues lie with women, 40% with men, 10% with both and 10% unexplained.

Declan Keane, Senior Embryologist and Director of ReproMed Clinics says, “we are seeing more and more Irish males coming to our clinics. Advances in technology have allowed us to offer greater insight into male fertility issues and we see men of all ages attending here to avail of our services. It’s important that couples seek advice to ensure that unnecessary tests are not carried out on women purely because satisfactory interest is not being taken in male issues.’’

Keane continues, ’’Many males attending our ReproMed clinics have expressed feelings of failure at not being able to provide healthy sperm to their partner to conceive their child naturally. This feeling of a loss of “masculinity”, while unwarranted, can lead to stress and strain on the relationship and in some cases depression.“

Gordon Ramsay talks about his infertility and his low sperm count. Hugh Jackman, Dennis Quaid and Robert De Niro are also vocal about their experiences of infertility. Keane believes that the stigma attached to infertility is preventing men talking about this hidden problem.

Neils Skakkebaek, a professor at the University of Copenhagen and co-author of the report says, ‘’The important impact of men’s reproductive health on a couple’s fertility is often overlooked’’.

The ESF study uncovered that 1 in 5 males aged 18-25 are affected by sub fertility – low semen quality and quantity. This can be caused by issues they are born with, such as undescended testes which later can be linked to testicular cancer in young males. Infertility can lead to stress; strain on relationships; and particularly in men, a feeling of failure. In the sub fertile general population, the majority of couples will eventually successfully become pregnant within a year with little or no intervention. This can come about through changes in lifestyle, diet and more often than not, a consultation with a fertility expert, which can help a couple to relax, leading to natural conception.

Fertility issues in men come in different forms:

· 15% of males are affected by a varicocele – an enlarged vein located in the scrotum which, if temperatures rise, can decrease the quantity and quality of sperm

· Undescended testicles is a common defect that males can be born with and can lead to fertility issues in the future

· Orchitis – inflammation in the testicles/genital tract is also a common cause of male infertility

· Unhealthy diet and lifestyle can also damage or interrupt sperm production

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Re: Din presa - despre infertilitate si/sau reproducere asis

Mesajde SOS Infertilitatea » Mie Oct 09, 2013 2:12 pm

Daily sex helps to reduce sperm DNA damage and improve fertility

Daily sex (or ejaculating daily) for seven days improves men’s sperm quality by reducing the amount of DNA damage, according to an Australian study presented today (Tuesday) to the 25th annual meeting of the European Society of Human Reproduction and Embryology in Amsterdam.

Until now there has been no evidence-based consensus amongst fertility specialists as to whether or not men should refrain from sex for a few days before attempting to conceive with their partner, either spontaneously or via assisted reproduction.

Dr David Greening, an obstetrician and gynaecologist with sub specialist training in reproductive endocrinology and infertility at Sydney IVF, Wollongong, Australia, said: “All that we knew was that intercourse on the day of ovulation offered the highest chance of pregnancy, but we did not know what was the best advice for the period leading up to ovulation or egg retrieval for IVF.

“I thought that frequent ejaculation might be a physiological mechanism to improve sperm DNA damage, while maintaining semen levels within the normal, fertile range.”

To investigate this hypothesis, Dr Greening studied 118 men who had higher than normal sperm DNA damage as indicated by a DNA Fragmentation Index (DFI). Men who had a more than 15% of their sperm (DFI >15%) damaged were eligible for the trial. At Sydney IVF, sperm DNA damage is defined as less than 15% DFI for excellent quality sperm, 15-24% DFI for good, 25-29% DFI for fair and more than 29% DFI for poor quality; but other laboratories can have slightly different ranges.

The men were instructed to ejaculate daily for seven days, and no other treatment or lifestyle changes were suggested. Before they started, levels of DNA damage ranged between 15% and 98% DFI, with an average 34% DFI when measured after three days’ abstinence. When the men’s sperm was re-assessed on the seventh day, Dr Greening found that 96 men (81%) had an average 12% decrease in their sperm DNA damage, while 22 men (19%) and an average increase in damage of nearly 10%. The average for the whole group dropped to 26% DFI.

Dr Greening said: “Although the mean average was 26% which is in the ‘fair’ range for sperm quality, this included 18% of men whose sperm DNA damage increased as well as those whose DNA damage decreased. Amongst the men whose damage decreased, their average dropped by 12% to just under 23% DFI, which puts them in the ‘good’ range. Also, more men moved into the ‘good’ range and out of the ‘poor’ or ‘fair’ range. These changes were substantial and statistically highly significant.

“In addition, we found that although frequent ejaculation decreased semen volume and sperm concentrations, it did not compromise sperm motility and, in fact, this rose slightly but significantly.

“Further research is required to see whether the improvement in these men’s sperm quality translates into better pregnancy rates, but other, previous studies have shown the relationship between sperm DNA damage and pregnancy rates.

“The optimal number of days of ejaculation might be more or less than seven days, but a week appears manageable and favourable. It seems safe to conclude that couples with relatively normal semen parameters should have sex daily for up to a week before the ovulation date. In the context of assisted reproduction, this simple treatment may assist in improving sperm quality and ultimately achieving a pregnancy. In addition, these results may mean that men play a greater role in infertility than previously suspected, and that ejaculatory frequency is important for improving sperm quality, especially as men age and during assisted reproduction cycles.”

Dr Greening said he thought the reason why sperm quality improved with frequent ejaculation was because the sperm had a shorter exposure in the testicular ducts and epididymis to reactive oxygen species – very small molecules, high levels of which can damage cells. “The remainder of the men who had an increase in DFI might have a different explanation for their sperm DNA damage,” he concluded.

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Re: Din presa - despre infertilitate si/sau reproducere asis

Mesajde SOS Infertilitatea » Mar Oct 15, 2013 2:21 pm

De ce unii bărbaţi nu pot avea copii? Ar putea fi vorba despre alimente banale, consumate zilnic, care reduc fertilitatea

Bărbaţii care consumă zilnic mezeluri au şanse mai mici de a deveni taţi: aceste alimente, chiar în cantităţi mici, reduc semnificativ calitatea spermei, arată un studiu american.


Ori de câte ori o femeie se întreabă, îngrijorată: "De ce nu rămân gravidă?", ar trebui să ia în considerare şi obiceiurile alimentare ale partenerului ei.

Un studiu realizat de specialişti de la Universitatea Harvard a analizat obiceiurile alimentare a 156 de bărbaţi care participau la tratamente de fertilizare in vitro, împreună cu partenerele lor.

Bărbaţii au fost chestionaţi cu privire la obiceiurile lor alimentare, cercetătorii urmărind să afle cât de des şi în ce cantităţi consumau aceştia mezeluri, carne albă, carne roşie, peşte alb, ton sau somon.

S-a constatat că, la bărbaţii care consumau fie şi o jumătate de porţie de mezeluri zilnic – o felie de bacon sau un cârnăcior – doar 5,5% dintre spermatozoizi aveau formă şi dimensiuni normale; la bărbaţii care consumau mai rar mezeluri, proporţia spermatozoizilor normali era de 7,2%.

În schimb, la bărbaţii care mâncau peşte alb cel puţin odată la două zile – sau o jumătate de porţie pe zi – calitatea spermei era mult mai bună decât la cei are mâncau doar ocazional peşte.

Cercetătorii recomandă, prin urmare, bărbaţilor care vor să-şi mărească şansele de a deveni taţi, să renunţe la mezeluri şi să consume, în schimb, peşte. Consumul unor peşti precum cod sau halibut (o specie de peşte plat, asemănător cu calcanul) are un efect benefic pronunţat asupra fertilităţii, afirmă cercetătorii.

Nu se cunoaşte precis cauza pentru care unele alimente reduc fertilitatea, iar altele o sporesc; cercetătorii cred că, în cazul de faţă, carnea roşie (folosită la prepararea mezelurilor) ar conţine cantităţi mari de pesticide care ar interfera cu hormonii umani; în schimb, peştele conţine cantităţi mari de zinc, element care, se crede, ar stimula fertilitatea.

Rezultatele întăresc concluziile altor studii, care arătau că şansele unui cuplu de a avea copii sunt puternic influenţate de stilul de viaţă al partenerilor: fumatul, consumul de alcool şi stresul reduc fertilitatea, în vreme ce exerciţiul fizic şi o alimentaţie sănătoasă sporesc şansele de a concepe un copil.

Alţi experţi, precum dr. Allan Pacey, director al British Fertility Society, au fost mai prudenţi în afirmaţii. Dr. Pacey a declarat că, deoarece ştim încă puţine lucruri despre relaţia dintre fertilitatea masculină şi diferite alimente, iar studiul a fost restrâns, concluziile ar trebui verificate prin cercetări viitoare mai ample. Totuşi, aminteşte el, există dovezi că anumite alimente chiar îmbunătăţesc fertilitatea; de pildă, la bărbaţii care consumă cantităţi mai mari de fructe şi legume proaspete, calitatea spermei este mai bună. În plus, se ştie deja că un consum ridicat de mezeluri este asociat cu diferite probleme de sănătate, astfel încât a recomanda bărbaţilor să limiteze consumul de mezeluri ar fi un lucru util pentru sănătatea lor în general şi, foarte posibil, şi pentru fertilitatea lor.

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Re: Din presa - despre infertilitate si/sau reproducere asis

Mesajde SOS Infertilitatea » Dum Oct 20, 2013 7:07 pm


'Mini-IVF,' using fewer drugs, sees greater success in women over 35


A new form of in-vitro fertilization requiring a low dose of the drug Clomid over a longer period has shown better results than conventional IVF in women over 35 and women over 40, the doctor who developed the treatment said.


A new IVF treatment has been found to have twice the success rates as the conventional method, and worked especially well for older women.

A new IVF treatment, dubbed mini-IVF, has been found to have twice the success rates as the conventional method, especially for women aged 35-45. Plus the new technique uses fewer drugs and can be done during a woman's lunch hour, rather than half a day, scientists say.

The method, developed by an IVF pioneer, Dr. Sherman Silber, is about half the price of traditional IVF treatments. Even better, the treatment has virtually no side effects, The Telegraph reports.

"This is a very significant breakthrough," he reportedly said at this week's American Society for Reproductive Medicine conference in Boston, where he shared findings from a trial of 520 women. "It was amazing to see the results, especially in women over the age of 40." Silber practices at the Infertility Center of St. Louis, Missouri.

For the method, women take a low dose of the fertility drug Clomid for 10 to 12 days -- by taking low dosages of standard medication over a longer period, women were found to avoid the problem of premature ovulation and produced eggs of better quality. Once the eggs are large enough, around 10 days later, doctors can remove them during a five-minute operation that doesn't require general anesthesia.

Success rates for women over 35 were found to be a third higher with the new treatment compared to women undergoing conventional IVF. The results were even better among women over 40 years, with the new method twice as likely to result in pregnancy compared to the conventional fertility treatment.

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Re: Din presa - despre infertilitate si/sau reproducere asis

Mesajde SOS Infertilitatea » Dum Oct 20, 2013 7:29 pm

Study Shows IVF Increases Pregnancy Rates By 20%

10/18/2013

The procedure known as endometrial scratching may significantly improve the rate of pregnancy, according to a researcher from the University of Nottingham.

The results from the clinical trial, which were obtained by a team of Brazilian scientists in collaboration with Dr Nick Raine-Fenning of the Nottingham University, showed the benefits of the precise timing of endometrial scratching.

Reports have shown that the increase in clinical pregnancy rate of women with IVF and ICSI treatment to be 49 percent, which is a big improvement from the current average of 29 percent.

The study will be presented at the ISUOG World Congress in Sydney.

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Re: Din presa - despre infertilitate si/sau reproducere asis

Mesajde SOS Infertilitatea » Sâm Oct 26, 2013 12:55 pm

Acupuncture IVF Fertility Treatment Success - New Research


Acupuncture and moxibustion increase pregnancy rates for women undergoing IVF, in vitro fertilisation. New research examined the effects of acupuncture and moxibustion on 84 infertile patients who had a minimum of 2 unsuccessful IVF fertility procedures. The participants were randomly divided into a control group, a sham (simulated) acupuncture group and a true acupuncture group. The acupuncture group showed a much higher clinical success rate for enhancing the IVF procedure than both the sham and control groups. The acupuncture group had a 35.7% success rate whereas the sham group had a 10.7% success rate and the control group had a 7.1% success rate.

Acupuncture and moxibustion help IVF fertility treatments. The goal of the study was to determine if acupuncture and moxibustion could increase the viability of an IVF procedure for patients who have had at least two prior failed IVF procedures. Acupuncture demonstrated significant clinical efficacy along with the moxibustion treatment. Moxibustion was applied to acupuncture points UB18, UB22, UB23, UB52, CV3, CV4, CV5, CV7 and GV4. Acupuncture needling was administered on the first and seventh days during which ovulation was medically induced. Acupuncture was also administered on the day prior to medical intervention of the ovary and on the day after the embryo transfer.

This clinical study comes at a time when many acupuncture and Chinese Medicine procedures have been proven effective in other research. One recent study demonstrated that acupuncture is significantly more effective than Clomifene, trademarked as Clomid and Omifin, for the treatment of infertility. The acupuncture group demonstrated a 76.3% effective rate for the induction of ovulation whereas the clomifene had only a 48.1% effective rate. In a related study, acupuncture was also shown to be effective for ovulation induction for women with PCOS, polycystic ovarian syndrome. Acupuncture successfully normalized sex steroid and hormone levels while simultaneously increasing ovulation frequency.

Perhaps one of the most important pieces of research to be published recently was that of acupuncture’s ability to increase live birth rates. It was discovered that women receiving acupuncture who are undergoing IVF treatments have a higher success rate if they receive acupuncture on the day of the embryo transfer. A team of researchers from University of Washington (Seattle), Oregon College of Oriental Medicine (Portland) and Northwest Center for Reproductive Sciences (Kirkland, Washington) developed a specific protocol that consistently demonstrated an increase in live birth rates. Acupuncture was applied to acupuncture points DU20, CV6, ST29, SP8, P6, and LV2 prior to embryo transfer along with auricular points Uterus and Endocrine on the right ear and Shenmen and Brain on the left ear. After the embryo transfer a different set of body style acupuncture points were applied: LI4, SP10, ST36, SP6, K3. These were accompanied with auricular acupuncture points Uterus and Endocrine on the right ear and Shenmen and Brain on the left ear.

In yet another scientific discovery, electroacupuncture demonstrated significant clinical results in improving live birth rates for women receiving IVF. The biochemical mechanisms by which acupuncture exerts its beneficial effects was revealed. A special protein increases in the blood when electroacupuncture is applied and that protein is directly proportional to higher live birth rates. The researchers discovered that electroacupuncture increases blood and embryo levels of HLA-G. Enhanced presence of the HLA-G protein is predictive of higher pregnancy and live birth rates. In addition to this biochemical finding, the statistical increase in live birth rates and pregnancy rates was medically significant. The scientists remarked, “the pregnancy outcome and the pregnancy rate are improved” for all women when electroacupuncture is applied.

Acupuncture and herbal medicine have also received a lot of attention for their ability to resolve chronic conditions of pelvic inflammatory disease, PID. This condition is often the result of an infection and is a leading cause of infertility. In the USA, over 100,000 women become infertile every year due to PID. The Healthcare Medicine Institute addresses this concern in its ongoing live webinar acupuncture CEU series for the treatment of PID. To view a sample of this educational material, view the following video clip below.




Sursa.
I always wondered
why somebody didn’t do
something about that,
then I realized
I AM SOMEBODY.

[...and you, and you!]

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